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Ancient DNA reveals pervasive directional selection across West Eurasia - Nature
- Latest findings show hundreds of alleles were shaped by directional selection in the past 10,000 years across West Eurasia.
- The study challenges the idea that hard sweeps were common in recent human evolution.
- Researchers analyzed 15,836 West Eurasians, including 10,016 with new data.
- Certain allele shifts relate to modern traits like body fat, schizophrenia, and cognitive performance.
- The team estimated selection coefficients at 9.7 million variants.
- Data come from aligned ancient sequences and reference panels used in imputation and analysis.
- The study provides multiple lines of evidence to support directional selection signals.
- An interactive web app and code accompany the study for replication and exploration.
- The data release includes a 15-year embargo on some metadata for accessibility.
- The work integrates ancient DNA with modern reference data to map selection across populations.
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