8legs: University of auckland

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Dug that slows aging has unintended consequences, study finds

Latest study shows rapamycin may reduce exercise gains in seniors, despite planned timing.
Researchers found memory of rapamycin’s long presence in the body may blunt muscle repair after workouts.
Study participants on rapamycin reported more side effects, including headaches and fatigue.
Experts caution rapamycin remains an immunosuppressant with approved use in organ transplantation.
Researchers say rapamycin’s non-selective action makes it difficult to separate aging benefits from muscle maintenance.
The trial involved 40 sedentary adults in their 70s, split 1:1 between rapamycin and placebo.
The study’s main finding: placebo participants gained more chair-stand repetitions than those on rapamycin.
Doctors timed dosing to avoid immediate post-exercise windows, but benefits were still reduced.
The drug’s long half-life means it lingers during subsequent workouts.
The study was led by Dr. Brad Stanfield and University of Auckland researchers.
Bottom line: rapamycin may slow aging via autophagy but can hinder post-exercise muscle repair.

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