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Millions of breast cancer patients could avoid chemotherapy with new genome test

#1 out of 3176.4K est. views83.33%

health9h ago

Millions of breast cancer patients could avoid chemotherapy with new genome test

Independent.co.uk

The Optima trial tracked over 4,400 patients and used the Prosigna genomic test to guide treatment decisions.
Low Prosigna scores (≤60) correlated with similar outcomes whether chemotherapy was given or not.
Five-year survival and recurrence-free rates remained high without chemotherapy for low-score patients.
Experts say results support reducing chemotherapy use for hormone-sensitive breast cancer.
Researchers call Optima a robust, practice-changing study for personalized cancer care.
Experts caution more research is needed to confirm benefits for men and younger patients.
The Optima trial involved hormone-sensitive breast cancer patients after initial surgery.
Low-score patients received hormone therapy alone rather than chemotherapy.
Outcomes for low-score patients were comparable to those who had chemotherapy.
The study highlights the potential for more personalized, targeted cancer care.

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Groundbreaking genomic test could spare millions of breast cancer patients chemotherapy

#2 out of 3

health1d ago

Groundbreaking genomic test could spare millions of breast cancer patients chemotherapy

Theguardian.com and 2 more

A large international trial using the Prosigna gene test indicates many breast cancer patients with hormone receptor-positive disease can safely forgo chemotherapy and rely on hormone therapy, preserving outcomes.
The trial enrolled over 4,000 adults aged 40+ across the UK, Norway, Sweden, Australia, New Zealand and Thailand, underscoring broad international applicability.
Prosigna analyzes 50 genes to estimate recurrence risk and guide chemotherapy decisions, enabling personalised treatment planning.
Five-year outcomes show near-identical survival between low-score patients who skipped chemo and those who received it, supporting safe treatment de-escalation.
UCL researchers emphasise personalising care to reduce unnecessary chemotherapy across health systems by basing decisions on tumour biology rather than traditional features alone.
Findings presented at a major global cancer conference (ASCO) underscore the study's international relevance and potential practice impact.
NHS implications suggest more than 5,000 patients annually could avoid chemotherapy thanks to genomically guided decisions.
Trial participant Karen Bonham describes the relief of avoiding chemotherapy, highlighting a real-world shift toward life realignment and normalcy post-diagnosis.
Health systems could benefit from more efficient, evidence-based resource use due to genomically guided decisions, potentially transforming guideline development.
The new evidence aligns with a broader move toward precision oncology by identifying who truly benefits from chemotherapy and who does not.
Guardian coverage places Optima results within ongoing debates about treatment value, reinforcing patient-centered decision-making.

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'Don’t be yourself' in the workplace, actually, Columbia professor says. Here’s why authenticity is 'overrated' | Fortune

#3 out of 3

business5h ago

'Don’t be yourself' in the workplace, actually, Columbia professor says. Here’s why authenticity is 'overrated' | Fortune

Fortune.com

A Columbia and University College London professor argues authenticity at work is overrated and not linked to leadership talent.
Leaders may be better off adjusting their behavior to the situation and team needs rather than showcasing their full personal self.
Meta-analysis from the University of Reading found managing impressions can boost leadership effectiveness across tasks and relationships.
The piece notes Gen Z’s entry into the workforce heightening the authenticity debate around workplace norms.
Public voices in the debate include comments from Marc Andreessen and Suzy Welch on authenticity at work.
The article frames authenticity as a nuanced trait, not a simple virtue for leadership success.
New York Times and other voices contribute to the broader discussion about transparency in leadership.
The piece references a broader discussion about bringing one’s whole self to work and its consequences.
Fortune notes the story is based on an excerpt of Chamorro-Premuzic’s book and related Harvard Business Review online piece.
The article ties authenticity to modern workplace dynamics, including office norms and management expectations.

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