8legs: Université de genève

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First-ever 3D view shows how killer T cells destroy cancer

Scientists reveal the first 3D view of how killer T cells attack cancer inside real tumors.
The study used cryo-expansion microscopy to preserve near-native cell structure during imaging.
Researchers found a dome-like membrane at the T cell contact point linked to adhesion and organization.
The team extended imaging to human tumor tissues to observe T cells infiltrating tumors in situ.
Cytotoxic granules can vary, sometimes containing one or more cores with concentrated active molecules.
The findings may help refine cancer immunotherapies by clarifying immune cell mechanics in tumors.
The study was conducted by UNIGE and CHUV researchers with ISREC TANDEM program support.
The work was published in Cell Reports, detailing molecular architecture of T cells and immune synapses.
The research highlights how the immune synapse coordinates toxic molecule release to target cells.
The findings span from isolated cells to human tumor tissues for clinical relevance.

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