8legs: The bad skin clinic

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I've had thrush for 30 years — it's so painful I avoid having sex

In the UK, Danni-Lea Sandland says thrush has persisted for 30 years, affecting her life and health in various ways.
She and her son Clay Bishop were diagnosed with STAT-1 gain-of-function (GOF) after appearing on The Really TV show The Bad Skin Clinic.
GOF is described as a genetic disorder where immune cells are over-activated, increasing infection and autoimmune risk.
The family relies on home antifungal infusions and faces planned stem cell transplants and chemotherapy for future relief.
Danni-Lea describes social stigma, wearing gloves at work, and avoiding social contact due to visible symptoms.
Experts note that GOF can cause thrush in the mouth, skin, and nails, reflecting widespread immune involvement.
Danni-Lea’s son Clay showed GOF-like symptoms after birth, prompting their joint investigation on the TV program.
The article notes that GOF is rare, with only about 400 reported cases worldwide.
Sandland aims to raise awareness of STAT-1 GOF and its signs to help others get timely diagnosis.

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