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Using Digital Multidomain Lifestyle Interventions for Alzheimer Disease Prevention: Tatsuhiro Hisatsune, PhD | NeurologyLive - Clinical Neurology News and Neurology Expert Insights
- A six‑month randomized trial found that personalized wearable‑based notifications improved cognition in older adults compared with usual care.
- MoCA scores rose more in the intervention group (change 1.0) than in controls (0.2).
- Frailty status improved more with the intervention (−0.3 vs −0.1).
- Researchers used wearables and smartphone data to monitor activity and sleep.
- Study authors emphasized the burden on caregivers and patients and sought digital solutions to reduce it.
- The CTAD 2025 conference provided the backdrop for these findings.
- The team discussed preclinical work on anserine as a potential cognitive support.
- The findings suggest multidomain interventions could be studied across different populations worldwide.
- The study points to wearable-based strategies as a practical approach for monitoring lifestyle factors.
- The reference cites a 2025 CTAD abstract and confirms a randomized trial design.
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