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UC San Diego Study Uncovers Molecular “Shield” Behind Cancer Immunotherapy Resistance
- A UC San Diego study shows blocking miR-25 improves tumors' response to immunotherapy across multiple cancer models.
- Researchers identify the miR-25–SDC3 pathway as a potential target to convert cold tumors to hot.
- Removing miR-25 reshapes the tumor environment and activates anti-tumor immune responses.
- The study, led by Tariq Rana, was published May 20, 2026, in Nature Communications.
- miR-25 suppression facilitates reactivation of anti-tumor immune responses in the tumor microenvironment.
- The research centers on immunotherapy resistance arising from the tumor microenvironment.
- miR-25 acts as a suppressor of SDC3, a protein linked to therapy response.
- The study traveled across multiple cancer models to verify the effect.
- Scientists see potential for therapies targeting the miR-25–SDC3 pathway.
- UC San Diego researchers emphasize the study's potential to broaden immunotherapy effectiveness.
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