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health4h ago
Roots of Many Miscarriages Could Trace Back To Before The Mother Is Even Born
- A large IVF study analyzed 139,416 embryos from 22,850 parent sets to map genetic risks for pregnancy loss.
- Maternal meiosis genes linked to chromosome pairing and recombination are associated with higher miscarriage risk.
- Variant in gene SMC1B tied to reduced crossover counts and increased maternal aneuploidy risk.
- Researchers say large sample sizes were essential to detect small genetic effects in pregnancy outcomes.
- Study links maternal age with aneuploidy, but genetic factors also play a role beyond age.
- Study included data from pre-implantation genetic testing of IVF embryos to identify risk patterns.
- Findings align with model organism studies, showing conserved meiotic genes affecting recombination.
- Researchers say results provide a foundation for future research into parental genetic variations related to pregnancy loss.
- Nature published the study, underlining its contribution to reproductive genetics.
- Researchers emphasize the need to combine IVF data with parental information for insights into miscarriage risk.
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