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Scientists tested vitamin D for COVID and found an unexpected long COVID clue
- Mass General Brigham trial finds high-dose vitamin D3 did not reduce COVID-19 severity or hospital visits.
- Researchers observed a possible signal that vitamin D could influence long COVID outcomes.
- The VIVID Trial enrolled 1,747 adults with COVID-19 and 277 household contacts across the United States and Mongolia.
- Adherence to the vitamin D regimen showed a potential link to fewer long COVID symptoms eight weeks after infection.
- The Journal of Nutrition published the randomized trial results in 2026.
- Study authors call for further research in larger populations to confirm long COVID effects.
- Funding and disclosures note support from foundations and vitamin D suppliers.
- The VIVID Trial used a regimen of 9,600 IU/day for two days, then 3,200 IU/day for four weeks.
- Household contacts of COVID-19 patients were included to assess transmission impact.
- The trial balanced groups with stratified randomization and statistical weighting.
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