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health2h ago
Flu drugs might fight cognitive decline seen in HIV, early study hints
- Latest development shows flu drugs may help reduce HIV-related cognitive decline by preserving immune-regulating glycans.
- Study used mouse models and blood samples from people with HIV on ART to explore links between glycans and cognitive impairment.
- Researchers identified loss of certain glycans, including sialic acid and galactose, as linked to cognitive decline in HIV.
- The findings were more pronounced in women, prompting questions about menopause and estrogen's role.
- Sialidase inhibitors, including components of Tamiflu, may reverse inflammation and protect cognition in the models.
- Researchers describe the work as proof-of-concept for glycans driving HIV-related inflammaging and cognitive decline.
- Long-term aim is precision medicine: test glycan levels and treat accordingly to prevent cognitive impairment.
- ART remains essential but does not fully prevent aging and cognitive decline in HIV patients.
- The study analyzed a mechanism involving glycan degradation and immune inflammation as a potential treatment target.
- The work opens doors for future interventions that either prevent glycans from degrading or replace them.
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