8legs: Korea advanced institute of science and technology

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Scientists Identify an Epigenetic Switch That Can Slow Production of Fat Cells

Researchers show an epigenetic switch can slow fat cell production by altering the Hippo-YAP/TAZ pathway in mice.
Blocking PPARγ’s fat‑cell instructions kept cells in a less specialized state and reduced adipocyte formation in mouse models.
When Hippo pathway brakes were released in mice, YAP and TAZ became hyperactive and fat cells regressed toward precursor-like states.
The study suggests epigenetic regulation plays a key role in adipocyte identity and could inform metabolic disease therapies.
The work was published in Science Advances, signaling a foundation for future personalized approaches to metabolic diseases.

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