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Possible Therapeutic Targets for Kidney Disease Identified
- Researchers at MU School of Medicine identified several genes that may be targeted to treat chronic kidney disease.
- Some genes showed higher activity in CKD models, indicating their role in kidney damage.
- The team plans to determine where these genes are expressed and study effects of moderating their activity.
- Findings published in Kidney360 support pursuing therapies to delay dialysis or transplantation for CKD patients.
- Chade emphasizes the potential to extend quality life for CKD patients by new therapies.
- MU researchers collaborated with NextGen Precision Health on the CKD study.
- The activity of specific genes may influence inflammation, fibrosis, and new blood vessel growth in CKD.
- Researchers plan to explore potential unintended effects of gene modulation on other organs.
- Chade is a leading author and NextGen Precision Health investigator.
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