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science1d ago
Scientists Identify 'Master Regulator' Behind Alzheimer's Problematic Proteins
- Researchers identify OTULIN as a possible master regulator of genes linked to brain aging and neurodegeneration.
- Blocking OTULIN activity reduced the Alzheimer’s-related protein tau in human neuron cultures.
- Complete removal of the OTULIN gene halted tau production in neurons studied.
- OTULIN also influences RNA metabolism and gene expression beyond tau.
- Researchers caution OTULIN targeting is not yet feasible for therapy due to broad bodily roles.
- Findings point to OTULIN as a potential new target for anti-aging and neurodegeneration research.
- RNA sequencing revealed OTULIN removal affects inflammation-related gene activity in neurons.
- The study appeared in Genomic Psychiatry and used human tissue cultures and stem-cell–derived neurons.
- Scientists emphasize OTULIN’s role in clearing cellular waste including tau tangles.
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