8legs: Journal of extracellular vesicles

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Scientists Restore Memory In Aging Mice Using a Simple Nasal Spray

TX A&M researchers report two intranasal doses reduced brain inflammation and improved memory in aging mice.
The spray uses extracellular vesicles from human stem cells to deliver therapeutic microRNAs to the brain.
After two doses, treated mice outperformed controls on object recognition and spatial memory tasks.
Researchers say the therapy could one day replace invasive procedures or months of medication.
The study focused on microglia in the hippocampus, a region critical for memory.
Researchers note the approach appears universal across sexes in mice.
The therapy aims to reach the brain with minimal invasiveness through nasal delivery.
MicroRNAs within the EVs regulate gene expression to reduce brain inflammation.
The aging mice were 18 months old, roughly equivalent to humans in their late 50s to 60s.
The findings were published in the Journal of Extracellular Vesicles and parallel other EV-related research.

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