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health1d ago
Scientists discover inherited traits that break Mendel’s Laws of genetics
- A mouse study found about 7% of epigenetic inheritance patterns did not follow Mendel's expectations across three generations.
- Researchers documented 54 emergent inheritance events where methylation appeared in offspring without parental marks.
- The study reports the first known naturally occurring paramutation in a mammal at Capn11.
- Findings suggest environmental factors may influence epigenetic inheritance across generations.
- Long-read DNA sequencing helped distinguish methylation patterns from genetic sequence differences.
- Imprinting was observed in five additional genes beyond previously known cases.
- Researchers tracked DNA methylation across three generations of mice aged 4–6 months.
- The work was supported by NIH, NSF, and Texas A&M health sciences funds.
- Researchers used collaboration across Johns Hopkins, Texas A&M, and other institutions to study inheritance mechanisms.
- Results may influence how scientists integrate genomics and epigenomics to understand disease risk.
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