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Top 6 genetics News Today

#1
James Watson exemplified the best and worst of science – from monumental discoveries to sexism and cutthroat competition
#1 out of 61.1K est. views0.00%
1d ago

James Watson exemplified the best and worst of science – from monumental discoveries to sexism and cutthroat competition

  • James Watson helped establish DNA’s double-helix significance and catalyzed the birth of molecular biology, shaping modern genetics.
  • Watson’s public persona blends monumental scientific impact with controversial, sometimes harmful, viewpoints on race and gender.
  • Rosalind Franklin’s essential data underpinned the DNA discovery, prompting ongoing debates about attribution and credit.
  • Watson’s epilogue remarks and book portrayals reflect ongoing discussion about Franklin’s rightful role in the discovery.
  • The scientific community has evolved toward better author attribution and accountability to honor all contributors.
  • Watson’s legacy remains a paradox: enormous scientific contributions shadowed by racist and sexist remarks.
  • Watson opposed gene patents during the Human Genome Project era, highlighting debates over intellectual property in biology.
  • The piece situates Watson within a broader movement toward inclusive scientific norms and fair credit.
  • The analysis connects Watson’s story to ongoing efforts to recognize contributors and ensure fair credit in science.
  • The Time obituary narrative presents Watson as a brilliant but deeply flawed figure whose ideas about race and intelligence linger in memory.
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#2
CRISPR gene-editing works to reduce high cholesterol in a new study
#2 out of 6243.3K est. views66.67%
health9h ago

CRISPR gene-editing works to reduce high cholesterol in a new study

https://www.npr.org/2025/11/08/nx-s1-5587748/crispr-gene-editing-cholesterol-heart-diseasehttps://seekingalpha.com/news/4519046-crispr-updates-early-stage-trial-data-heart-disease-drug
Npr.org and 1 more
  • A small early trial found a one-time CRISPR-based drug reduced cholesterol and triglycerides in participants.
  • The treatment targets ANGPTL3 in the liver to lower cholesterol and triglycerides.
  • The study involved 15 volunteers and was presented at the American Heart Association’s annual meeting.
  • Researchers cautioned that long-term safety and broader applicability require more study.
  • Experts say more research is needed to confirm protective effects against cardiovascular disease.
  • The findings were published in a peer-reviewed journal alongside the conference presentation.
  • CRISPR Therapeutics and Verve Therapeutics are among companies developing similar approaches.
  • Heart disease remains the leading cause of death, highlighting the potential impact if results hold.
  • Cost considerations and long-term safety remain unknown factors for real-world use.
  • The study uses a liver-targeted knockout of ANGPTL3 to reduce lipid levels.
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#3
The multifaceted roles of non-coding RNAs in cell-cell communication in cardiovascular health and disease - Cell & Bioscience
#3 out of 6
health1d ago

The multifaceted roles of non-coding RNAs in cell-cell communication in cardiovascular health and disease - Cell & Bioscience

  • The latest review explains that extracellular vesicles, RNA-binding proteins and lipoproteins carry non-coding RNAs to heart cells, enabling paracrine and endocrine signaling.
  • MicroRNAs are a central focus of ncRNA communication in the heart, with carriers protecting and delivering them to target cells.
  • Long non-coding RNAs (lncRNAs) are highlighted as emerging mediators in extracellular RNA signaling within cardiovascular disease.
  • HDL particles can transport miRNAs to endothelial cells, influencing gene expression via SR-BI uptake.
  • LncRNA-enriched exosomes from mesenchymal stem cells show cardioprotective effects in various models.
  • RBPs like AGO2 are prominent carriers of circulating miRNAs, though their cellular origins remain unclear.
  • The ERCC framework is proposed to classify ncRNA cargo types across carriers for better CCC understanding.
  • Lipoproteins such as HDL, LDL and VLDL are linked to ncRNA carriage and cardiovascular signaling.
  • Single-cell RNA sequencing is highlighted as a tool to reveal ncRNA dynamics in the heart.
  • EV heterogeneity complicates ncRNA cargo identification and necessitates standardized approaches.
  • The review notes gaps in understanding the cellular origin and uptake mechanisms of ncRNA carriers in CVD.
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#4
In Pictures: The race to discover the secrets of DNA
#4 out of 6562.0 est. views
20h ago

In Pictures: The race to discover the secrets of DNA

  • Watson and Crick developed a two‑chain, helical DNA model by testing possible structures against existing data in the Cavendish Laboratory.
  • Rosalind Franklin’s Photo 51 provided crucial clues about DNA’s helical shape used in the final model.
  • A new draft of 'A Structure for DNA' circulated in March 1953 as the Cambridge scientists prepared their Nature submission.
  • Linus Pauling published a competing model that was eventually deemed incorrect.
  • The Nobel Prize in 1962 honored Watson, Crick, and Wilkins for their work on nucleic acids’ structure and information transfer.
  • Rosalind Franklin’s role remains a topic of debate regarding recognition in the discovery process.
  • Crick and Watson’s approach combined model-building with evaluation against existing research.
  • The discovery opened new frontiers in science and laid groundwork for future advancements.
  • The public record notes ongoing discussions about credit in historical scientific achievements.
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#5
The premier, the poet and the fight to save an extraordinary Australian frog
#5 out of 6
17h ago

The premier, the poet and the fight to save an extraordinary Australian frog

  • Scientists are applying DNA testing to search for proof of life of the southern gastric-brooding frog in its former habitats.
  • The frog, once thought extinct in 2000, drew global attention to amphibian conservation amid Queensland politics and activism.
  • The story centers on Rheobatrachus silus, the southern gastric-brooding frog, famed for giving birth through its mouth.
  • Researchers documented the frog’s unique breeding biology during the early 1970s discovery era in Queensland.
  • Conservation efforts in the Conondales and Blackall ranges were intertwined with political figures and environmental campaigns.
  • Chytrid fungus caused the decline of the gastric-brooding frog, sealing its fate as an extinct species in 2000.
  • FrogID Week and citizen science are cited as paths for potential rediscovery in Australia.
  • Experts note that rediscovery remains uncertain, but hope persists among scientists and enthusiasts.
  • The article links the frog’s fate to broader lessons about Australia’s conservation movement and governance.
  • The piece underscores the frog’s enduring cultural and scientific legacy in Australia.
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#6
A woman's cancer seemed incurable. Identifying a rare genetic condition saved her life.
#6 out of 686.5K est. views
health9h ago

A woman's cancer seemed incurable. Identifying a rare genetic condition saved her life.

  • Diane Davis's advanced ovarian cancer was initially deemed incurable before molecular testing revealed Lynch syndrome.
  • Lynch syndrome increases cancer risk and helps explain Davis's family history of cancer.
  • Checkpoint inhibitors were used after genetic testing, enabling the immune system to target cancer.
  • Davis received pembrolizumab every three weeks and saw rapid tumor reduction.
  • Within two treatments, a newly identified pelvic mass disappeared and lymph node cancer receded.
  • Davis's Lynch syndrome diagnosis prompted her daughter to start early cancer screenings.
  • Davis has remained in complete remission for six years following treatment.
  • The case demonstrates how molecular testing can reframe prognosis and guide options.
  • Davis credits immunotherapy for restoring her health after chemotherapy failure.
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