8legs: Diabetes

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#1 out of 216.67%

A BMJ study found seven hours and 18 minutes as the sweet spot for nightly sleep to help insulin sensitivity.
Weekend extra sleep may help those with weekday debt but can worsen glucose metabolism for others.
Consistent sleep between seven to eight hours per night is associated with healthy blood sugar levels.
The study used estimated glucose disposal rate as a marker of insulin resistance.
The research analyzed data from about 23,000 US adults who tracked sleep nightly.
An observational design means no direct cause-and-effect conclusions can be drawn.
The researchers say sleep patterns may be relevant for metabolic regulation in diabetes.
Poor sleep can increase inflammation, blood pressure, and stress hormones according to the study.
The BMJ Open Diabetes Research & Care study drew on international data but focused on a US adult cohort.
Authors note a potential vicious cycle where metabolic dysregulation disrupts normal sleep patterns.

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#2 out of 2

health11h ago

New brain mechanism for metformin: low doses affect blood sugar via Rap1 in the VMH, not just liver or gut.
Rap1 suppression in VMH is essential for metformin’s glucose-lowering effect at low doses.
SF1 neurons in the VMH activate in response to metformin entering the brain.
Direct brain administration showed metformin lowers glucose at doses thousands of times smaller than oral doses.
The study links brain Rap1 signaling to metformin’s broader potential beyond diabetes.
Researchers aim to map Rap1 pathways to explore metformin’s neurological effects further.
The finding challenges the view that metformin works only via liver and gut mechanisms.
The study used genetically engineered mice lacking Rap1 in VMH to test metformin’s effect.
Researchers note metformin may influence brain aging, prompting further research.
The team plans to design drugs that target Rap1 or related mechanisms for precision therapy.

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