#1
#1 out of 198.84%
health3h ago
I've had thrush for 30 years — it's so painful I avoid having sex
- In the UK, Danni-Lea Sandland says thrush has persisted for 30 years, affecting her life and health in various ways.
- She and her son Clay Bishop were diagnosed with STAT-1 gain-of-function (GOF) after appearing on The Really TV show The Bad Skin Clinic.
- GOF is described as a genetic disorder where immune cells are over-activated, increasing infection and autoimmune risk.
- The family relies on home antifungal infusions and faces planned stem cell transplants and chemotherapy for future relief.
- Danni-Lea describes social stigma, wearing gloves at work, and avoiding social contact due to visible symptoms.
- Experts note that GOF can cause thrush in the mouth, skin, and nails, reflecting widespread immune involvement.
- Danni-Lea’s son Clay showed GOF-like symptoms after birth, prompting their joint investigation on the TV program.
- The article notes that GOF is rare, with only about 400 reported cases worldwide.
- Sandland aims to raise awareness of STAT-1 GOF and its signs to help others get timely diagnosis.
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