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health1h ago
The First AI-Designed Vaccine Was Just Tested on Humans. It Could Change How We Fight Pandemics
- A Cambridge-led team tested an AI-designed DNA vaccine in 39 healthy adults, finding it safe and well tolerated.
- The vaccine targets conserved sarbecovirus features to try to elicit cross-reactive immune responses.
- Results show modest antibody responses with some recognition of conserved regions, but no robust neutralizing activity yet.
- The vaccine uses non-replicating plasmid DNA and is designed to be needle-free, aiding logistics and storage.
- Researchers describe the approach as moving vaccine development from reactive to future-proof planning.
- A larger Phase 2 trial with about 200 people is planned to evaluate immune responses more broadly.
- The study was conducted amid Omicron waves, complicating separation of the vaccine’s effect from prior infection.
- The research is part of a broader push for universal vaccines against virus families like sarbecoviruses and influenza.
- Experts emphasize the need for ongoing trials to determine protective efficacy beyond safety.
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