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health6h ago
Dug that slows aging has unintended consequences, study finds
- Latest study shows rapamycin may reduce exercise gains in seniors, despite planned timing.
- Researchers found memory of rapamycin’s long presence in the body may blunt muscle repair after workouts.
- Study participants on rapamycin reported more side effects, including headaches and fatigue.
- Experts caution rapamycin remains an immunosuppressant with approved use in organ transplantation.
- Researchers say rapamycin’s non-selective action makes it difficult to separate aging benefits from muscle maintenance.
- The trial involved 40 sedentary adults in their 70s, split 1:1 between rapamycin and placebo.
- The study’s main finding: placebo participants gained more chair-stand repetitions than those on rapamycin.
- Doctors timed dosing to avoid immediate post-exercise windows, but benefits were still reduced.
- The drug’s long half-life means it lingers during subsequent workouts.
- The study was led by Dr. Brad Stanfield and University of Auckland researchers.
- Bottom line: rapamycin may slow aging via autophagy but can hinder post-exercise muscle repair.
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