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Lab-grown organoids reveal how glioblastoma outsmarts treatment
- UCLA reports two organoid models that mimic human brain tumors to study glioblastoma in a near-human environment.
- The HOTT model reveals communication pathways and a regulator named PTPRZ1 that influences tumor behavior.
- Researchers linked PTPRZ1 in tumor and brain cells to tumor aggressiveness.
- Reducing PTPRZ1 in brain cells altered tumor behavior without changing tumor cells directly.
- The iHOTT model adds immune components to study responses to immunotherapy.
- Pembrolizumab activated immune cells but did not eliminate tumor growth in organoids.
- Diversity of T cells increased with pembrolizumab, but responses were patient-specific.
- iHOTT reproduced patient-like immune responses in a human-relevant system.
- Organoid models may guide more personalized therapies for glioblastoma.
- The UCLA studies were funded by multiple foundations and institutes.
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