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health3h ago
A Painful Side Effect of Statins Explained After Decades of Mystery
- New evidence links statins to calcium gate leakage in muscle cells via RyR1, offering a potential cause of SAMS.
- Statins may keep the gate open, allowing calcium to leak and damage muscle tissue, explaining persistent pain and cramps.
- Researchers tested statin-intolerant mice with Rycal drugs and stopped the calcium leakage, improving weakness.
- Two future paths: redesign statins to avoid RyR1 binding or use Rycal therapies to curb SAMS.
- About 40 million U.S. adults take statins, with roughly 10% experiencing SAMS and stopping use.
- The study does not apply to all SAMS cases but could help identify at-risk people.
- Findings published in the Journal of Clinical Investigation reinforce the new mechanism for SAMS.
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