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Top 5 american society of clinical oncology News Today

#1
Cancer survivors may see surprising benefits from one specific exercise, study says
#1 out of 579.06%
health1h ago

Cancer survivors may see surprising benefits from one specific exercise, study says

  • A clinical trial found yoga reduced insomnia, fatigue, and mood issues in cancer survivors.
  • The Yoga for Cancer Survivors program (YOCAS) ran four weeks with three weekly sessions.
  • Most participants were female breast-cancer survivors.
  • Researchers noted improvements in mood and fatigue linked to yoga.
  • Experts say yoga offers a non-pharmaceutical option for symptom relief.
  • The study was funded by the National Cancer Institute and reported by ASCO.
  • Yoga classes were delivered in a supportive, peer-driven environment.
  • Lead researchers emphasized yoga as a non-drug approach to improve daily function.
  • The trial involved three weekly yoga sessions over four weeks.
  • The report notes yoga’s potential to help with anxiety and fatigue in survivorship.
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#2
Cancer jab can eradicate entire tumours in patients, trial shows
#2 out of 595.71%
health3h ago

Cancer jab can eradicate entire tumours in patients, trial shows

  • New cancer jab amivantamab induced tumour shrinkage or disappearance in 43 of 102 patients across an 11-country trial.
  • The three-action jab targets EGFR and MET and boosts immune attack on tumours.
  • Patients with head and neck cancers benefited, including those who had not HPV-related disease.
  • Median overall survival after starting treatment was 12.5 months amid challenging disease.
  • The jab is administered under the skin, offering quicker, outpatient treatment.
  • The study spanned 11 countries and involved patients with advanced disease after other therapies failed.
  • Johnson & Johnson developed amivantamab, now under evaluation in around 60 clinical trials.
  • Martin Harrington of ICR called the responses unprecedented for resistant cancers.
  • Researchers plan to expand the approach to other cancer types with ongoing trials.
  • Trial results will be presented at ASCO, the world’s largest cancer conference.
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#3
Groundbreaking genomic test could spare millions of breast cancer patients chemotherapy
#3 out of 5
health1d ago

Groundbreaking genomic test could spare millions of breast cancer patients chemotherapy

https://www.theguardian.com/society/2026/may/29/groundbreaking-genomic-test-spare-breast-cancer-patients-chemotherapy-hormone-therapyhttps://www.bbc.com/news/articles/c2325j0xk1vohttps://www.dailymail.com/health/article-15859971/Millions-breast-cancer-patients-spared-chemotherapy-thanks-groundbreaking-gene-test.html
Theguardian.com and 2 more
  • A large international trial using the Prosigna gene test indicates many breast cancer patients with hormone receptor-positive disease can safely forgo chemotherapy and rely on hormone therapy, preserving outcomes.
  • The trial enrolled over 4,000 adults aged 40+ across the UK, Norway, Sweden, Australia, New Zealand and Thailand, underscoring broad international applicability.
  • Prosigna analyzes 50 genes to estimate recurrence risk and guide chemotherapy decisions, enabling personalised treatment planning.
  • Five-year outcomes show near-identical survival between low-score patients who skipped chemo and those who received it, supporting safe treatment de-escalation.
  • UCL researchers emphasise personalising care to reduce unnecessary chemotherapy across health systems by basing decisions on tumour biology rather than traditional features alone.
  • Findings presented at a major global cancer conference (ASCO) underscore the study's international relevance and potential practice impact.
  • NHS implications suggest more than 5,000 patients annually could avoid chemotherapy thanks to genomically guided decisions.
  • Trial participant Karen Bonham describes the relief of avoiding chemotherapy, highlighting a real-world shift toward life realignment and normalcy post-diagnosis.
  • Health systems could benefit from more efficient, evidence-based resource use due to genomically guided decisions, potentially transforming guideline development.
  • The new evidence aligns with a broader move toward precision oncology by identifying who truly benefits from chemotherapy and who does not.
  • Guardian coverage places Optima results within ongoing debates about treatment value, reinforcing patient-centered decision-making.
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#4
Trial of multi-cancer blood test among 142,000 NHS patients fails to meet main aim
#4 out of 5
health7h ago

Trial of multi-cancer blood test among 142,000 NHS patients fails to meet main aim

  • The trial enrolled 142,942 NHS patients aged 50 to 77 with no cancer symptoms and followed them for three years.
  • Results showed the primary endpoint—reduction in late-stage cancers—was not met.
  • Some secondary findings suggested a potential decline in stage four cancers, yet experts urged caution.
  • Grail described the findings as encouraging for some measures, while others remain uncertain.
  • Independent experts cautioned that the main outcome was not met and results should be interpreted carefully.
  • The trial was conducted within the NHS and presented at the ASCO annual meeting in Chicago.
  • Experts emphasized that mortality outcomes will be informative in a couple of years.
  • NHS England and NHS Improvement were involved in conducting the trial and evaluating its implications.
  • The Galleri test is produced by Grail, which defended the study's potential despite the primary endpoint result.
  • NHS leaders await detailed data to guide future decisions about population screening.
  • Overall, the study did not demonstrate a clear population-level benefit for Galleri within the trial period.
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#5
Pancreatic cancer is deadly and difficult to treat. A new pill could change that
#5 out of 5
health7h ago

Pancreatic cancer is deadly and difficult to treat. A new pill could change that

  • A new daily pill, daraxonrasib, targets the KRAS gene and shows promising survival in pancreatic cancer patients.
  • In early Phase 1/2 data, overall survival for patients on daraxonrasib reached about 13.2 months, near doubling standard care.
  • About one-third of patients with the KRAS G12 mutation showed an objective tumor response to the drug.
  • A 30% incidence of severe side effects, including rash and GI issues, accompanies daraxonrasib.
  • FDA fast-tracked limited approval raised access and equity questions for patients and providers.
  • Cost and affordability remain unresolved as doctors anticipate insurance coverage challenges.
  • Researchers aim to broaden use earlier in treatment and explore combinations with immunotherapy or surgery.
  • Revolution Medicines plans a full Phase 3 readout at the ASCO annual meeting to shape future approvals.
  • Experts see potential for the drug to alter the standard of care for PDAC if earlier use proves beneficial.
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