8legs: Alzheimer's association

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The 'age' of your blood could predict dementia risk, new study suggests

A new study links a blood-based biological age marker, MileAge delta, to higher dementia risk in a large UK Biobank cohort.
Higher MileAge delta means the blood profile appears older than expected, correlating with greater dementia risk.
The strongest association was with vascular dementia, especially for those with the APOE gene linked to Alzheimer's.
Genetic risk (APOE) combined with biological aging marks could markedly raise dementia risk, per study authors.
Researchers caution the study is observational and cannot prove causation between aging markers and dementia.
The UK Biobank data included more than 223,000 participants, with analyses based on a single blood measurement.
Experts say metabolomic aging may be modifiable through lifestyle changes to slow aging and dementia risk.
The MileAge measure compares metabolite-predicted age to actual age to estimate biological aging.
Study authors emphasize the need for broader validation before clinical use of MileAge in dementia risk prediction.
The study notes that participants were healthier and mainly of European descent, limiting generalizability.

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