8legs: Alejandro r. chade

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Possible Therapeutic Targets for Kidney Disease Identified

Researchers at MU School of Medicine identified several genes that may be targeted to treat chronic kidney disease.
Some genes showed higher activity in CKD models, indicating their role in kidney damage.
The team plans to determine where these genes are expressed and study effects of moderating their activity.
Findings published in Kidney360 support pursuing therapies to delay dialysis or transplantation for CKD patients.
Chade emphasizes the potential to extend quality life for CKD patients by new therapies.
MU researchers collaborated with NextGen Precision Health on the CKD study.
The activity of specific genes may influence inflammation, fibrosis, and new blood vessel growth in CKD.
Researchers plan to explore potential unintended effects of gene modulation on other organs.
Chade is a leading author and NextGen Precision Health investigator.

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