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science16h ago
This discovery could let bones benefit from exercise without moving
- Scientists identify Piezo1 as the bone’s mechanical sensor that links movement to bone growth.
- Activation of Piezo1 during activity limits fat in bone marrow and promotes bone formation in mice.
- Lack of Piezo1 causes fat cells to replace bone cells, accelerating bone loss.
- Researchers identify a signaling loop that links mechanosensing to bone regeneration.
- Findings point toward exercise-mimetic drugs for people who cannot move.
- Potential impact on osteoporosis treatment and independence for bedridden patients.
- Researchers seek clinical translation to protect bone health in vulnerable groups.
- Study published in Signal Transduction and Targeted Therapy.
- Interdisciplinary collaboration supported multiple funding sources.
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